Production of Liquid Drugs

Preparation for Production of Liquid Drugs

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Description

Description

Application

Centec preparation vessels are designed for the production of liquid drugs, infusion solutions, syrups and vaccines.

Description

Highest manufacturing standards, outstanding material quality and extremely precise process control guarantee the most efficient handling of valuable pharmaceutical products. For product preparation, the vessel is first filled with Water for Injection (WFI). Previously weighted raw materials (e. g. concentrates, powders) are then added and dissolved in the water by a circulation pump. For accurate level control, differential pressure meters and load cells are used. To achieve optimum and repeatable product formation, temperature and pressure inside the vessel are controlled within narrow limits. At the outlet of the vessel, the finished product runs through a sterile filter. For Centec preparation vessels a large range of optional equipment is available such as agitators, homogenizers, valves, measurement instruments, and sampling devices. The design of the vessels provides excellent cleaning and sterilization characteristics.

  • Vertical or horizontal; single or multi-wall design
  • Large range of optional components for high precision process Control
  • Skid mounted for easy installation and start-up
  • Hygienic execution and full CIP/SIP capability
  • According to applicable guidelines (e. g. cGMP, FDA, GAMP, ISPE)
  • Completely qualified (DQ, IQ, OQ) if desired

Typical Technical Data

Capacity 10 – 20.000 l (others on request)
Pressure of Operation – 1 – + 6 bar
Temperature of Operation max. 150 °C
Material 1.4404/1.4435/AISI 316L; etc.
Surface Finish Ra < 0,4 and others possible; electropolishing possible
Ferrite Content < 1 % possible
Optionen measurements of critical parameters such as e. g. pressure, temperature, concentration, pH, O2; insulation; agitator; homogenizer
About Centec

Products & Features

Centec Germany is a premier manufacturer of high-precision process sensors and fully automated skid-mounted systems for the beverage, food, pharmaceutical, and chemical industries. With 50 years of experience, they specialize in in-house development and ISO-certified manufacturing, providing tailored, turnkey solutions for liquids processing and quality measurement.

Sensors:

  • Density Measurement (RHOTEC)
  • Sound Velocity (SONATEC)
  • Combined Analysis (COMBITEC) for complex, multi-component liquids
  • O2 (Oxytrans)
  • CO2 (Carbotec)

Automated frame-mounted Process Skids:
These modular systems integrate their high-precision sensors directly into the production line, allowing for "plug-and-play" installation and seamless integration into existing plant automation for 

  • Water Treatment & Purification
  • Beverage & Liquid Processing
  • Cleaning & Sterilization

Key Benefits

  • Single Source Responsibility: Engineering, manufacturing, installation, and commissioning from one provider, reducing project complexity.
  • Superior Process Accuracy: Inline measurement of density, sound velocity, O2 and CO2 concentration ensures maximum product quality.
  • Increased Efficiency & Lower Costs: Optimized designs minimize space requirements and operational expenses.
  • Global Support: A worldwide network ensures fast service and technical support.